The MATISS Project was born in 1983-1984 (baseline) under the name
of Di.S.Co Project (Progetto Distretto Sezze Controllo Comunitario) as
a “demonstration project” on chronic degenerative diseases in Central
Italy, aimed at assessing the effectiveness of primary prevention
interventions on risk factors. After about 10 years of intervention,
no particular differences were found between the sample in treatment
and the sample control (Acta Cardiologia 1997).
The cohort was randomly selected from the population living in a
rural area about 100 km south of Rome comprising the municipalities of
Sezze, Bassiano, Roccagorga and Priverno. 3648 people aged 20-69 were
examined (participation rate 67%). In 1986-87, the same cohort was
reviewed together with the examination of a new sample extracted using
the same methodology. A total of 4827 people were examined
(participation rate 41%). These cohorts were reviewed in 1993-96
together with the examination of a new sample (5458 persons examined,
participation rate 60%) and data collection was supplemented by the
collection of blood samples stored in the
biobank at the
Istituto Superiore di Sanità (ISS, National Institute of Health).
Since 1993 the project has continued as a longitudinal study, called
MATISS, with follow-up of total and cause mortality and fatal and
non-fatal coronary and cerebrovascular events validated with MONICA
diagnostic criteria. The MATISS cohort is part of the international
projects MORGAN (MOnica Risk, Genetics, Archiving and Monograph) and
BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe).
- Population sample: cohort of general population enlisted in 4
municipalities of central Italy, 8512 men and women, age 20-80 years.
- Base line and review (year): 1983-84; 1986-87, 1993-96.
- Collection of biological samples (year): 1993-1996.
- Data collected at baseline and review: socio-demographic
characteristics; lifestyles (smoking habit, alcohol consumption, diet,
physical activity); risk factors (blood pressure, heart rate, ECG read
according to the Minnesota code, body mass index, total and HDL
cholesterol, triglyceridemia, glycaemia, respiratory function); in
1993-96 also included the examination of cognitive function and
physical performance in people aged 65 years and older.
- Biological samples: N=4489, serum, plasma, buffy coat, emazie.
- Follow-up data: total and cause mortality; fatal and non-fatal
coronary and cerebrovascular events validated with MONICA diagnostic
criteria; available until 2004.
Publications:
- Ursu SC, Pannozzo F, Palmieri L, Vestri A, Lo Noce C,
Giampaoli S. Incidenza
di malattie cardiovascolari maggiori e tumori nella coorte
longitudinale del Progetto MATISS in persone con differente
profilo di rischio cardiovascolare. Epidemiol Prev
2016;40:433-8.
- Veronesi G, Gianfagna F, Giampaoli S, Chambless LE, Grassi G,
Cesana G, Ferrario MM. Validity of
a long-term cardiovascular disease risk prediction equation for
low-incidence populations: The CAMUNI-MATISS Cohorts Collaboration
Study. Eur J Prev Cardiol 2015;22:1618-25.
- Donfrancesco C, Palleschi S, Palmieri L, Rossi B, Lo Noce C,
Pannozzo F, Spoto B, Tripepi G, Zoccali C, Giampaoli S. Estimated
glomerular filtration rate, all-cause mortality and cardiovascular
diseases incidence in a low risk population: the MATISS study.
PLoS One 2013;8(10):e78475.
- Trojani M, Palmieri L, Vanuzzo D, Donfrancesco C, Panico S,
Pilotto L, Dima F, Lo Noce C, De Sanctis Caiola P, Giannuzzi P,
Giampaoli S., a nome del Gruppo di Ricerca dell’Osservatorio
Epidemiologico Cardiovascolare. Attività
fisica lavorativa e nel tempo libero: come si è modificata nella
popolazione italiana? G Ital Cardiol 2006;7:487-497.
- Vescio MF, Davey Smith G, Giampaoli S. Socio-economic-position
overall and cause-specific mortality in an Italian rural
population. Eur J Epidemiol 2003;18:1051-1058.
- Kondili LA, Chionne P, Costantino A, Villano U, Lo Noce C,
Pannozzo F, Mele A, Giampaoli S, Rapicetta M. Infection
rate and spontaneous seroreversion of anti-hepatitis C virus
during the natural course of hepatitis C virus infection in the
general population. GUT 2002;50:693-696.
- Seccareccia F, Pannozzo F, Dima F, Minoprio A, Menditto A, Lo
Noce C, Giampaoli S. Heart
rate as a predictor of mortality: the MATISS Project. Am J
Public Health 2001;91(8):1258-1263.
- Vescio MF, Davey Smith G, Giampaoli S. Socio-economic
position and cardiovascular risk factors in an Italian rural
population. Eur J Epidemiol 2001;17:449-459.
- Capriani P, Palmieri L, Seccareccia F, Giampaoli S. Fattori di
rischio cardiovascolare, caratteristiche sociali e pattern
comportamentali: l’esperienza del Progetto MATISS. Psicologia
della salute 2000;2:35-47.
- Giampaoli S, Poce A, Sciarra F, Lo Noce C, Dima F, Minoprio A,
Santaquilani A, Caiola De Santis P, Volpe R, Menditto A, and
Urbinati GC. Change
in cardiovascular risk factor during 10 years of a community
intervention programme. Acta Cardiologia 1997; LII(5):411-422.
Giampaoli S, Urbinati GC, Menotti A, Ricci G. Short
term changes in cardiovascular risk factors in the Di.S.Co.
Intervention Project. Research Group of the DI.S.Co. Project.
Eur J Epidemiol. 1991;7:372-9.read
- Giampaoli S, Menotti A, Urbinati GC, Pannozzo F, Pasquali M,
Morisi G, Buongiorno AM, Dima F, Santaquilani A, Lo Noce C,
Lombari P e il Gruppo di Ricerca del Progetto Di.S.Co.: Il
progetto Distretto Sezze Controllo Comunitario delle malattie
cronico-degenerative (Di.S.Co.): dati relativi al secondo
screening di popolazione. Rapporto ISTISAN 1990, 90/16.
- Urbinati GC, Menotti A, Giampaoli S, Arca M, con la
collaborazione tecnica di M. Pasquali e del Gruppo di Ricerca del
Progetto Di.S.Co. Il progetto Distretto Sezze Controllo
Comunitario delle malattie cronico-degenerative (Di.S.Co.): dati
relativi all'esame iniziale. Rapporto ISTISAN 1988, 88/6.