CCM
Guadagnare Salute

Epidemiologia e prevenzione delle malattie cerebro e cardiovascolari

CCM

Population surveys

MATISS (Atherosclerotic diseases Istituto Superiore di Sanità)

The MATISS Project was born in 1983-1984 (baseline) under the name of Di.S.Co Project (Progetto Distretto Sezze Controllo Comunitario) as a “demonstration project” on chronic degenerative diseases in Central Italy, aimed at assessing the effectiveness of primary prevention interventions on risk factors. After about 10 years of intervention, no particular differences were found between the sample in treatment and the sample control (Acta Cardiologia 1997).

 

The cohort was randomly selected from the population living in a rural area about 100 km south of Rome comprising the municipalities of Sezze, Bassiano, Roccagorga and Priverno. 3648 people aged 20-69 were examined (participation rate 67%). In 1986-87, the same cohort was reviewed together with the examination of a new sample extracted using the same methodology. A total of 4827 people were examined (participation rate 41%). These cohorts were reviewed in 1993-96 together with the examination of a new sample (5458 persons examined, participation rate 60%) and data collection was supplemented by the collection of blood samples stored in the biobank at the Istituto Superiore di Sanità (ISS, National Institute of Health). Since 1993 the project has continued as a longitudinal study, called MATISS, with follow-up of total and cause mortality and fatal and non-fatal coronary and cerebrovascular events validated with MONICA diagnostic criteria. The MATISS cohort is part of the international projects MORGAN (MOnica Risk, Genetics, Archiving and Monograph) and BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe).

  • Population sample: cohort of general population enlisted in 4 municipalities of central Italy, 8512 men and women, age 20-80 years.
  • Base line and review (year): 1983-84; 1986-87, 1993-96.
  • Collection of biological samples (year): 1993-1996.
  • Data collected at baseline and review: socio-demographic characteristics; lifestyles (smoking habit, alcohol consumption, diet, physical activity); risk factors (blood pressure, heart rate, ECG read according to the Minnesota code, body mass index, total and HDL cholesterol, triglyceridemia, glycaemia, respiratory function); in 1993-96 also included the examination of cognitive function and physical performance in people aged 65 years and older.
  • Biological samples: N=4489, serum, plasma, buffy coat, emazie.
  • Follow-up data: total and cause mortality; fatal and non-fatal coronary and cerebrovascular events validated with MONICA diagnostic criteria; available until 2004.

Publications:

© Istituto Superiore di Sanita (ISS)